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Publications

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EVIDENCE → INFERENCE → CARE

Publications

Scholarship exploring skin cancer while advancing how medical evidence is generated, interpreted, and translated into care.

Selected Publications

Liquid Biopsy in Cutaneous Oncology: Current Practice and Future Directions

In this review, published in the Journal of the American Academy of Dermatology, we examine current liquid biopsy approaches and emerging applications across melanoma, Merkel cell carcinoma, cutaneous squamous cell carcinoma, basal cell carcinoma, and cutaneous T-cell lymphoma.

Jul 30, 2026
Sabah Choudhury, Adewunmi O. Adelaja, Haley Ann Neff, David M. Miller, Emily S. Ruiz, Ryan J. Sullivan, Rhoda M. Alani

Frontline Immunotherapy With Response-Guided Subsequent Treatment (FIRST) in Cutaneous Squamous Cell Carcinoma: A Bayesian Causal Analysis of Dose Intensity, Early Benefit, and Treatment De-escalation

In this original research article, published in the Journal for ImmunoTherapy of Cancer, we evaluate dose intensity, early clinical benefit, and response-guided treatment de-escalation among 189 patients receiving frontline immunotherapy for cutaneous squamous cell carcinoma.

Jul 20, 2026
David M. Miller, Ross D. Merkin, Howard L. Kaufman, Sameer G. Gupta, Natalie Wolkow, Adewunmi Adelaja, Ryan J. Sullivan, Chirayu Patel, Alexandra Sorrentino, Sonia Cohen, Christine Cimoch, Kevin S. Emerick

Local Recurrence After Excision of Merkel Cell Carcinoma: What Do We Actually Know, and What Should We Do Next?

In this Perspectives on the Science article, published in the Journal of Cutaneous Oncology, we examine local recurrence risk after complete excision of localized Merkel cell carcinoma, the role of postoperative radiation, the salvageability of isolated recurrence, and strategies for improving the evidence base.

Jul 16, 2026
David M. Miller, Kevin S. Emerick, Howard L. Kaufman, Aubriana M. McEvoy, Lisa Zaba, Ajay Sharma, Adewunmi Adelaja, Ann W. Silk, Nikhil I. Khushalani, Isaac Brownell, Daniel G. Coit, Paul Nghiem, Vernon K. Sondak

Perioperative Treatment Strategies for Advanced Melanoma and Non-Melanoma Skin Cancers

In this review, published in the Journal of the American Academy of Dermatology, we examine evolving neoadjuvant and perioperative treatment strategies across melanoma, cutaneous squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma.

Feb 1, 2026
Kennedy H. Sun, Sach Thakker, Jonathan Greenzaid, Micah Belzberg, David M. Miller, Vishal A. Patel

Locally Advanced Conjunctival Squamous Cell Carcinoma Not Responsive to Immune Checkpoint Inhibitor Therapy: 3 Cases and a Literature Review

In this case series and literature review, published in Ophthalmic Plastic and Reconstructive Surgery, we describe three patients with inferior-forniceal conjunctival squamous cell carcinoma who progressed during PD-1 blockade and examine how anatomic site and tumor mutational burden may relate to treatment response.

Jan 12, 2026
Natalie Wolkow, Nahyoung G. Lee, Kevin S. Emerick, Suzanne K. Freitag, Howard L. Kaufman, David M. Miller, Han-Ying P. Chang, Anna M. Stagner

Efficacy of Nivolumab Plus Relatlimab Versus BRAF/MEK Inhibitors for First-Line Treatment of BRAF-Mutant Advanced Melanoma

In this article, published in BMJ Oncology, we compare first-line nivolumab plus relatlimab with several BRAF/MEK inhibitor regimens in BRAF-mutant advanced melanoma using matching-adjusted indirect comparisons.

Dec 14, 2025
David M. Miller, James W. Smithy, Jennell Palaia, Divya Patel, Anthony Salvatore, David D’Adamo, Matthew Mattera, Zheng-Yi Zhou, Viviana Garcia-Horton, Ahmad A. Tarhini

Evolving Standards for Resected High-Risk CSCC: Integrating Insights from C-POST and KEYNOTE-630

In this Perspectives on the Science article, published in the Journal of Cutaneous Oncology, we examine the positive C-POST trial, the contrasting KEYNOTE-630 result, and the evolving role of adjuvant and neoadjuvant immunotherapy in resected high-risk cutaneous squamous cell carcinoma.

Sep 3, 2025
David M. Miller, Vishal A. Patel, Vernon K. Sondak, Vatche Tchekmedyian, Ross D. Merkin, Isaac Brownell, Reed E. Drews, Sameer Gupta, Nikhil I. Khushalani, Paul T. Nghiem, Howard L. Kaufman, Kevin S. Emerick

Dual Checkpoint Blockade in Merkel Cell Carcinoma: Lessons From CheckMate 358 and the Questions That Remain

In this Perspectives on the Science article, published in the Journal of Cutaneous Oncology, we examine CheckMate 358, the conflicting prospective evidence for nivolumab plus ipilimumab, and the unresolved questions surrounding efficacy, toxicity, patient selection, and therapeutic intent in advanced Merkel cell carcinoma.

Jun 14, 2025
David M. Miller, Vernon K. Sondak, Sunandana Chandra, Vatche Tchekmedyian, Ryan J. Sullivan, Ross D. Merkin, Vishal A. Patel, Adewole S. Adamson, Isaac Brownell, Reed E. Drews, Nikhil I. Khushalani, Shailender Bhatia, Paul T. Nghiem

The Evolving Role of ctDNA in Merkel Cell Carcinoma: Challenges and Opportunities

In this Perspectives on the Science article, published in the Journal of Cutaneous Oncology, we examine the evolving role of circulating tumor DNA in Merkel cell carcinoma surveillance, recurrence detection, risk stratification, and treatment decision-making.

Apr 2, 2025
David M. Miller, Vernon K. Sondak, Sunandana Chandra, Kenneth Y. Tsai, Howard L. Kaufman, Sameer Gupta, Isaac Brownell, Yoshine Saito, Ann W. Silk, Manisha Thakuria, Paul T. Nghiem

Immunotherapy for Advanced Conjunctival Squamous Cell Carcinoma: Treatment Failures

In this article, published in Ophthalmic Plastic and Reconstructive Surgery, we report a single-institution cohort of five patients with advanced conjunctival squamous cell carcinoma treated with immune checkpoint inhibitors, all of whom experienced disease progression.

Mar 13, 2025
D. Amee Azad, Jia Jia Zhang, Kevin S. Emerick, Sophia Z. Shalhout, Howard L. Kaufman, David M. Miller, Nahyoung G. Lee, Michael K. Yoon, Suzanne Freitag, Anna M. Stagner, Natalie Wolkow

The Evolving Treatment Landscape for CSCC

In this review, published in Archives of Dermatological Research, we examine how immune checkpoint inhibition is reshaping cutaneous squamous cell carcinoma care across advanced, neoadjuvant, adjuvant, intralesional, and immunopreventive settings—and consider the expanding role of dermatologists in treatment delivery and toxicity management.

Feb 26, 2025
David M. Miller

Comparing First-Line Immunotherapy in Advanced Melanoma: No Clear Winner?

In this Perspectives on the Science article, published in the Journal of Cutaneous Oncology, we examine an indirect treatment comparison of nivolumab plus relatlimab versus nivolumab plus ipilimumab for first-line advanced melanoma, focusing on efficacy, toxicity, methodology, patient selection, and the limits of cross-trial inference.

Feb 15, 2025
Yoshine Saito, David M. Miller, Isaac Brownell

Should Ipilimumab Be the New “Standard” for Refractory Merkel Cell Carcinoma?

In this editorial, published in the Journal of Cutaneous Oncology, we examine the evidence for ipilimumab plus nivolumab after anti–PD-1 or anti–PD-L1 failure in Merkel cell carcinoma and argue that the regimen is reasonable for selected patients but not yet established as a universal standard of care.

May 11, 2024
David M. Miller

Tumor-Infiltrating Lymphocyte Therapy Receives FDA Approval

In this editorial, published in the Journal of Cutaneous Oncology, we examine the accelerated approval of lifileucel, the first FDA-approved cellular therapy for melanoma, and consider its efficacy, toxicity, manufacturing demands, access barriers, and emerging role after immune checkpoint inhibitor failure.

May 1, 2024
Jennifer Strong, David M. Miller, Isaac Brownell

Neoadjuvant-Intent Immunotherapy in Advanced, Resectable Cutaneous Squamous Cell Carcinoma

In this article, published in JAMA Otolaryngology-Head & Neck Surgery, we present a cohort study of patients treated with neoadjuvant cemiplimab or pembrolizumab for advanced cSCC

Mar 28, 2024
Kim EY, Ruiz ES, DeSimone MS, Shalhout SZ, Hanna GJ, Miller DM, Schmults C, Rettig EM, Foreman RK, Sethi R, Thakuria M, Silk Ann W

The Prognostic Value of the Merkel Cell Polyomavirus Serum Antibody Test: A Dual Institutional Observational Study

In this preprint, subsequently published in Cancer, we evaluate the prognostic value of the Merkel Cell Polyomavirus serum antibody test

Mar 19, 2024
David M. Miller MD PhD, Sophia Z. Shalhout PhD, Kayla Wright, Matt Miller, Howard L. Kaufman MD5, Kevin S. Emerick MD, Harrison Reeder PhD, Ann W. Silk MD, Manisha Thakuria MD

Perspectives on Medical Aid in Dying: A Multifaceted Ethical Discussion

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the complex ethical considerations surrounding Medical Aid in Dying, integrating insights from a recent multi-institutional journal club discussion.

Mar 1, 2024
David Michael Miller, MD, PhD, Isaac Brownell, MD, PhD, Vatche Tchekmedyian, MD, Fishal A. Patel, MD, Howard Lane Kaufman, MD, Kevin Scott Emerick, MD

Imaging Surveillance for Stage III Melanoma: Should We Be Stalkers or Casual Observers?

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the role of surveillance imaging for patients with high-risk melanoma.

Feb 14, 2024
Kevin Scott Emerick, MD, David Michael Miller, MD, PhD

A multidisciplinary perspective on the role of Mohs micrographic surgery for invasive melanoma of the head and neck.

Jan 24, 2024
Lauren Ching, Jennifer Strong, Truelian Lee, Howard L. Kaufman, Kevin S. Emerick, Emily Y. Kim, Vishal A. Patel, Isaac Brownell, Kritika Singh, Victor A. Neel, David M. Miller, Sameer Gupta

Adjuvant Anti–PD-1 for Merkel Cell Carcinoma: Ready for the Clinic?

In this Perspectives on the Science article, published in the Journal of Cutaneous Oncology, we examine the ADMEC-O trial and whether adjuvant nivolumab should change clinical practice for patients with completely resected Merkel cell carcinoma.

Sep 11, 2023
David M. Miller, Jennifer Strong, Kevin S. Emerick, Sameer Gupta, Ann W. Silk, Isaac Brownell

To Screen or Not To Screen, That is the Question

In this Perspectives on the Science piece we reflect on the impact of the recent USPSTF recommendation statement on skin cancer screening.

Jul 30, 2023
Truelian Lee, David M. Miller, Howard L. Kaufman, Kevin S. Emerick, Sameer Gupta, Laura K. Ferris

Immunotherapy and Cardiovascular Health - A Cause for Concern?

In this Perspectives on the Science piece we reflect on the impact of ‘Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque’ by Drobni et al.

May 1, 2023
David M. Miller, Laura K. Ferris, Sameer Gupta, Isaac Brownell, Sophia Z. Shalhout

Perioperative Immunotherapy for High-Risk Resectable Melanoma - A New Standard?

In this Perspectives on the Science piece we reflect on the impact of the recently published SWOG S1801 trial.

Apr 15, 2023
Serena Vilasi, David M. Miller, Howard L. Kaufman, Kevin S. Emerick, Sophia Z. Shalhout, Emily Y Kim, Vishal A. Patel, Khalid Garmen, Sameer Gupta, Isaac Brownell

Skin Cancer Chemoprevention for Transplant Recipients - The Search Continues

In this Perspectives on the Science piece, we reflect on the impact of the recently published ONTRANS trial.

Mar 22, 2023
Howard L. Kaufman, Vishal A. Patel, Sophia Z. Shalhout, Sameer Gupta, Sonia Cohen, Isaac Brownell, David M. Miller

Surgical Factors Affecting Regionally Metastatic Cutaneous Squamous Cell Carcinoma to the Parotid Gland

Understanding the impact of surgical treatment on regionally metastatic cutaneous squamous cell carcinoma (cSCC) is important as treatment paradigms shift with the introduction of immune checkpoint inhibitors. Herein, we aim to describe surgical impact on outcomes for regionally metastatic cSCC

Feb 12, 2023
Vishwanatha M. Rao, Allen L. Feng, Daniel G. Deschler, Howard Kaufman; Derrick T. Lin, David M. Miller, Jeremy D. Richmon, Sophia Z. Shalhout, Mark A. Varvares, Kevin S. Emerick

Lacking Overall IMspiration for Triplet Therapy in Melanoma? A Review of the Interim Analysis of IMspire150.

In this Perspectives on the Science piece, we reflect on the impact of the recently published article by Ascierto et al. in Lancet Oncology that provides interim results from IMspire150.

Feb 4, 2023
David M. Miller, Kevin S. Emerick, Vishal A. Patel, Sonia Cohen, Isaac Brownell, Donald P. Lawrence

Targeting TBK1 to overcome resistance to cancer immunotherapy

We demonstrate that targeting TBK1 is a novel and effective strategy to overcome resistance to cancer immunotherapy.

Jan 11, 2023
Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, Fu A, Ma X, Gwee J, Tiwari P, Du PP, Sindurakar P, Tian J, Mehta A, Schneider AM, Yizhak K, Sade-Feldman M, LaSalle T, Sharova T, Xie H, Liu S, Michaud WA, Saad-Beretta R, Yates KB, Iracheta-Vellve A, Spetz JKE, Qin X, Sarosiek KA, Zhang G, Kim JW, Su MY, Cicerchia AM, Rasmussen MQ, Klempner SJ, Juric D, Pai SI, Miller DM, Giobbie-Hurder A, Chen JH, Pelka K, Frederick DT, Stinson S, Ivanova E, Aref AR, Paweletz CP, Barbie DA, Sen DR, Fisher DE, Corcoran RB, Hacohen N, Sorger PK, Flaherty KT, Boland GM, Manguso RT, Jenkins RW

Therapy with oncolytic viruses: progress and challenges

We review the available data and provide guidance on optimizing the use of oncolytic viruses in clinical practice.

Jan 10, 2023
Sophia Z. Shalhout, David M. Miller, Kevin S. Emerick, Howard L. Kaufman

Tumor-Infiltrating Lymphocyte Therapy for Advanced Melanoma: Ready for Prime Time?

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the impact of the recently published article “Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma”.

Jan 9, 2023
Emily Y Kim, Sophia Z. Shalhout, Howard L. Kaufman, Kevin S. Emerick, Vishal A. Patel, Khalid Garmen, Isaac Brownell, David M. Miller

StoryboardR - An R Package and Shiny Application Designed to Visualize Real-World Data From Clinical Patient Registries

We created StoryboardR, an R package and Shiny application facilitates the data visualization of real-world data from tumor registries captured in REDCap®.

Jan 5, 2023
David M. Miller, Sophia Z. Shalhout

Neoadjuvant Nivo/Rela for Resectable Melanoma

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the impact of the recently published article Neoadjuvant relatlimab and nivolumab in resectable melanoma.

Dec 5, 2022
David M. Miller, Howard L. Kaufman, Kevin S. Emerick, Justine V. Cohen, Emily Y Kim, Sophia Z. Shalhout

Ipi/Nivo for Advanced MCC

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the impact of the recently published article “Combined Nivolumab and Ipilimumab with or without Stereotactic Body Radiation Therapy for Advanced Merkel cell carcinoma - A Randomised, Open Label, Phase 2 Trial”.

Nov 21, 2022
Sophia Z. Shalhout, Justine V. Cohen, Khalid Garmen, Emily Y Kim, Sonia Cohen, David M. Miller

Neoadjuvant ICI for Resectable CSCC

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the impact of the recently published article Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma.

Nov 8, 2022
David M. Miller, Vishal A. Patel, Justine V. Cohen, Khalid Garmen, Sophia Z. Shalhout

Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network

We present the results of a clinical pilot to standardize precision oncology workflows. This was published in The Oncologist in November 2022.

Nov 2, 2022
Dias-Santagata, Dora and Heist, Rebecca S et al.

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

We present a prosepective study of neoadjuvant cemiplimab in high-risk resectable CSCC. This study was published in the New England Journal of Medicine in September 2022.

Sep 11, 2022

A Retrospective Study of Ipilimumab Plus Nivolumab in Anti–PD-L1/PD-1–Refractory Merkel Cell Carcinoma

In this article, published in the Journal of Immunotherapy, we report a dual-institution retrospective study of ipilimumab plus nivolumab in patients with advanced Merkel cell carcinoma refractory to prior anti–PD-1 or anti–PD-L1 therapy.

Jul 28, 2022
Sophia Z. Shalhout, Kevin S. Emerick, Howard L. Kaufman, Ann W. Silk, Manisha Thakuria, David M. Miller

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of nonmelanoma skin cancer

Society guidelines for the management of NMSC. Published in the Journal for ImmunoTherapy of Cancer, July 2022.

Jul 27, 2022

Immunotherapy for Nonmelanoma Skin Cancer: Facts and Hopes

We review the latest trends in cancer care for Nonmelanoma skin cancer. Published in Clinical Cancer Research, June 2022.

May 31, 2022
Sophia Z. Shalhout, Howard L. Kaufman, Kevin S. Emerick, David M. Miller

Generalizable EHR-R-REDCap Pipeline for a National Multi-Institutional Rare Tumor Patient Registry

We present a clinical informatics pipeline designed to capture large-scale structured laboratory EHR data.

Dec 18, 2021

BodyMapR - An R Package and Shiny Application Designed to Generate Anatomical Visualizations of Cancer Lesions

R package for enhanced visualizations of cancer lesions

Dec 10, 2021
David M. Miller, Sophia Z. Shalhout

Impact of an Evolving Regulatory Landscape on Skin Cancer Drug Development in the U.S

We present an analysis of the impact of an evolving regulatory landscape on skin cancer drug development.

Nov 13, 2021

Assessing Changes in Clinical Perineural Invasion during Immunotherapy for Head and Neck Cutaneous Squamous Cell Carcinoma

We report on the clinical experience of treating with immunotherapy for head and neck Cutaneous Squamous Cell Carcinoma.

Nov 10, 2021
Michael Wu, Katherine L Reinshagen, Mary Beth Cunnane, Sophia Z. Shalhout, Howard Kaufman, David M. Miller, Kevin S Emerick

The Merkel Cell Carcinoma Patient Registry-From Promise to Prototype to Patient

We present a white paper outlining the objectives and applications of the Merkel Cell Carcinoma Patient Registry.

Nov 9, 2021
Miller DM, Shalhout SZ, Saqlain F, Patel VA, Tsai Kenneth Y, Komandur R, Louv B, Wong MK

GENETEX - A GENomics Report TEXt Mining R Package and Shiny Application Designed to Capture Real-World Clinico-Genomic Data

We created GENETEX, an R package and Shiny application for text mining genomic reports from EHR and direct import into REDCap®.

Sep 27, 2021
David M. Miller, Sophia Z. Shalhout

Diagnostic yield of staging brain magnetic resonance imaging is low in Merkel cell carcinoma - A single-institution cohort study

Journal: Journal of the American Academy of Dermatology (preprint). Accepted September 6, 2021. Please see the postprint on the JAAD Website.
Sep 5, 2021

A proof-of-concept study of plasma cell-free DNA sequencing for disease detection, surveillance, and clinical decision-making in Merkel cell carcinoma.

Aug 31, 2021
Sophia Z. Shalhout, Kevin S. Emerick, Howard L. Kaufman, David M. Miller

Immunotherapy for Non-Melanoma Skin Cancer

We review the latest trends in cancer care for Non-Melanoma skin cancer.

Aug 26, 2021

Evaluation of clinical characteristics and pre-biopsy impressions of primary Merkel cell carcinoma of the skin

Journal: Dermatology Online Journal (postprint). Accepted August 13, 2021. © The Regents of the University of California, Davis campus. Please see the publisher’s version on…
Aug 19, 2021
Farees Saqlain, Sophia Z Shalhout, David M. Miller

Immune Checkpoint Inhibition in Marjolin Ulcer - A Case Series

We provide a case series in the Journal of Immunotherapy of response to anti-PD1 therapy in Marjolin Ulcer.

Jun 19, 2021
Sophia Z. Shalhout, Howard L. Kaufman, Ryan J. Sullivan, Donald Lawrence, David M. Miller

Commentary on Surgical Margins in MCC

We provide commentary on a recent publication in JAMA Dermatology entitled “Surgical Margins Larger Than 1 cm and Overall Survival in Patients With Merkel Cell Carcinoma”.…
Apr 6, 2021
David M. Miller, Kevin Emerick

Microsatellitosis in Merkel cell carcinoma - a staging quandary

We provide an analysis in the Dermatology Online Journal of microsatellitosis in a cohort of MCC patients.

Mar 14, 2021
Farees Saqlain, Sophia Z. Shalhout, Kayla-Wright, David M. Miller

Evaluation of the Fragility of Pivotal Trials Used to Support US Food and Drug Administration Approval for Plaque Psoriasis

In this original research article, published in the Journal of the American Academy of Dermatology, we evaluate the statistical robustness of 69 primary and co-primary endpoints from pivotal trials supporting FDA approvals for systemic plaque psoriasis therapies.

Feb 1, 2021
Sophia Z. Shalhout, Romi Bloom, Lynn Drake, David M. Miller

Real-world assessment of response to anti-PD1 therapy in advanced cutaneous squamous cell carcinoma

In the JAAD, we provide a real-world assessment of response to anti-PD1 therapy in advanced cutaneous squamous cell carcinoma.

Jan 14, 2021
Sophia Z. Shalhout, John Chul Park, Kevin S. Emerick, Ryan J. Sullivan, Howard L. Kaufman, David M. Miller

A REDCap-Based Operational Tool to Guide Care Coordination in a Multidisciplinary Cutaneous Oncology Clinic

We’re excited to share our recently published manuscript at JCO OP describing a REDCap-Based Operational Tool to Guide Care Coordination in a Multidisciplinary Cutaneous…
Nov 12, 2020
Farees Saqlain, Sophia Z. Shalhout, Keith T. Flaherty, Kevin S. Emerick, David M. Miller

Clinical landscape of oncolytic virus research in 2020

We provide an overview of the clinical landscap of oncolytic virus research.

Oct 7, 2020
Nicholas Macedo, David M. Miller, Rizwan Haq, Howard L Kaufman

Metastatic Merkel Cell Carcinoma Masquerading as multiple immune-related Adverse Events

We present a case of MCC masquerading as Multiple Immune-Related Adverse Events

Sep 29, 2020
Farees Saqlain, Sophia Z. Shalhout, Kevin S. Emerick, Thomas G. Neilan, Tatyana Sharova, David M. Miller

Regionally Metastatic Merkel Cell Carcinoma Associated with Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis

We present a case of MCC presenting with NMDA Receptor Encephalitis.

Sep 25, 2020
Sophia Z. Shalhout, Kevin S. Emerick, Peter M. Sadow, Jenny J. Linnoila, David M. Miller

TdT Expression Is a Marker of Better Survival in Merkel Cell Carcinoma, and Expression of B-Cell Markers Is Associated With Merkel Cell Polyomavirus

TdT expression is a potential marker of better survival in Merkel cell carcinoma.

Jun 7, 2020
Mai P Hoang, Piotr Donizy, Cheng-Lin Wu, Janusz Kopczynski, Malgorzata Pieniazek, David M. Miller, Janusz Ryś
 

Generalized Acquired Cutis Laxa Associated with Monoclonal Gammopathy of Dermatological Significance

We present a case of Acquired Cutis Laxa associated with Monocloncal Gammopathy of Monoclonal Significance.

Feb 12, 2020
Sophia Z. Shalhout, Myrna R. Nahas, Reed E. Drews, David M. Miller
 

Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity

Inhibition of Haspin kinase may overcome drug resistance in melanoma, modulate the immune environment and target a vulnerability in different cancer lineages.

Dec 28, 2019
Melms, Johannes C. and Vallabhaneni, Sreeram and Mills, Caitlin E. and Yapp, Clarence and Chen, Jia-Yun and Morelli, Eugenio and Waszyk, Patricia and Kumar, Sushil and Deming, Derrick and Moret, Nienke and Rodriguez, Steven and Subramanian, Kartik and Rogava, Meri and Cartwright, Adam N.R. and Luoma, Adrienne and Mei, Shaolin and Brinker, Titus J. and Miller, David M. and Spektor, Alexander and Schadendorf, Dirk and Riggi, Nicolo and Wucherpfennig, Kai W. and Sorger, Peter K. and Izar, Benjamin

Clinical Spectrum of Cutaneous Melanoma Morphology

In this original research article, published in the Journal of the American Academy of Dermatology, we use consensus clustering of 400 prebiopsy photographs to define five recurrent morphologic patterns of cutaneous melanoma and characterize their clinical and pathologic features.

Jan 1, 2019
Nikolai Klebanov, Nicole S. Gunasekera, William M. Lin, Elena B. Hawryluk, David M. Miller, Bobby Y. Reddy, Mitalee P. Christman, Derek Beaulieu, Suvithan Rajadurai, Lyn M. Duncan, Arthur J. Sober, Hensin Tsao
 

Kaposi’s varicelliform eruption in a patient with metastatic melanoma and primary cutaneous anaplastic large cell lymphoma treated with talimogene laherparepvec and nivolumab

We present a case of Eczema Tvecium secondary to T-Vec

Oct 31, 2018
David M. Miller, Ryan M. Trowbridge, Anupam Desai, Reed E. Drews
 

High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma

Cutaneous melanoma is an aggressive tumor that accounts for most skin cancer deaths. Among the physiological barriers against therapeutic success is a strong survival…
Jun 30, 2018
Eliades, Philip and Abraham, Brian J. and Ji, Zhenyu and Miller, David M. and Christensen, Camilla L. and Kwiatkowski, Nicholas and Kumar, Raj and Njauw, Ching Ni and Taylor, Michael and Miao, Benchun and Zhang, Tinghu and Wong, Kwok-Kin and Gray, Nathanael S. and Young, Richard A. and Tsao, Hensin
 

A Complete Response in cSCC with Ipi/Nivo

Although most cases of metastatic cutaneous Squamous Cell Carcinoma mCSCC can be cured with local therapy, up to 8,000 deaths occur each year. With no US Food and Drug…
Sep 7, 2017
David M. Miller, Faulkner-Jones, B. E., Stone, J. R., Drews, R. E.
 

Somatic Driver Mutations in Melanoma

Somatic driver mutations in melanoma.
May 18, 2017
Bobby Reddy, David M. Miller, Hensin Tsao
 

A novel multi-CDK inhibitor P1446A-05 restricts melanoma growth and produces synergistic effects in combination with MAPK pathway inhibitors

We present a novel multi-CDK inhibitor that restricts melanoma growth

Jul 1, 2016
Eliades P, Miller DM, Miao B, Kumar R, Taylor M, Buch S, Srinivasa SP, Flaherty KT, Tsao H.
 

Molecularly Targeted Therapies and Immunotherapies For Melanoma

Current status and future directions of molecularly targeted therapies and immunotherapies for melanoma.
May 31, 2016
Miller DM, Flaherty KT, Tsao H
 

CDKs as Therapeutic Targets in Melanoma

Cyclin-dependent kinases as therapeutic targets in melanoma. Miller and Flaherty (2014)
May 16, 2016
David M. Miller, Keith T Flaherty
 

Molecular testing in melanoma

We present an overview of the role of molecular testing in melanoma

Apr 30, 2016
David M. Miller, Keith T. Flaherty, Hensin Tsao
 

Parameters for Establishing Humanized Mouse Models

Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice…
Mar 31, 2010
Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL.
 

TLR Activation Abrogates Mixed Chimerism

TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
Nov 30, 2008
Miller DM, Thornley T, Pearson T, Yamazaki M, Brehm MA, Rossini AA, Greiner DL.
 

Viral infection - a potent barrier to transplantation tolerance

Viral infection: a potent barrier to transplantation tolerance.
Jun 25, 2008
Miller DM, Thornley T, Rossini AA, Greiner DL
 

TLR Agonists Abrogate Immunological Tolerance

TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Apr 30, 2008
Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL
 

Role of Innate Immunity in Transplantation Tolerance

Role of Innate Immunity in Transplantation Tolerance.
Mar 31, 2008
Miller DM, Rossini AA, Greiner DL
 

Different mechanisms control peripheral and central tolerance

Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. Yamazaki et al. (2007)
Jun 8, 2007
Yamazaki, M., T. Pearson, M. A. Brehm, D. M. Miller, J. A. Mangada, T. G. Markees, L. D. Shultz, J. P. Mordes, A. A. Rossini, and D. L. Greiner.
 

Jellypin - a lower eukaryotic serine proteinase inhibitor (serpin)

Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin. Cole et al. (2004)
Sep 20, 2004
Cole, Elisabeth B. and Miller, David and Rometo, David and Greenberg, Robert M. and Brömme, Dieter and Çataltepe, Sule and Pak, Stephen C. and Mills, David R. and Silverman, Gary A. and Luke, Cliff J.
 

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.
Mar 4, 2002
Al-Khunaizi M1, Luke CJ, Askew YS, Pak SC, Askew DJ, Cataltepe S, Miller D, Mills DR, Tsu C, Brömme D, Irving JA, Whisstock JC, Silverman GA
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