/* ========================================================================
   LVD 2026 — MELANOMA UPDATES FOR THE DERMATOLOGIST
   Quarto / Reveal.js design system
   Source of truth for HTML → PNG → PowerPoint export

   Organization follows the QMD slide order:
   00 global/reset → 01 three updates → 02 section break →
   03 MERLIN design → 04 missed endpoint → 05 question reframing →
   06 MERLIN validation → 07 MERLIN timeline/integration → 08 section break →
   09 CheckMate 067 → 10 section break → 11–13 RP1 → 14 take-home
   ======================================================================== */

:root {
  --lvd-navy: #28365f;
  --lvd-navy-dark: #18233f;
  --lvd-cobalt: #4058b3;
  --lvd-cobalt-bright: #526bc8;
  --lvd-teal: #2e8483;
  --lvd-teal-dark: #226b6c;
  --lvd-coral: #c96f61;
  --lvd-coral-dark: #a9534d;
  --lvd-sand: #d9b978;
  --lvd-sand-dark: #b8924f;
  --lvd-ink: #1d2943;
  --lvd-muted: #68717d;
  --lvd-paper: #fbfaf7;
  --lvd-white: #ffffff;
  --lvd-border: #dce1e9;
  --lvd-soft-blue: #f2f4fa;
  --lvd-soft-teal: #eef7f6;
  --lvd-soft-coral: #fbf1ee;
  --lvd-soft-sand: #fbf6e9;
  --shadow: 0 14px 34px rgba(34, 48, 84, 0.09);
  --shadow-soft: 0 8px 18px rgba(34, 48, 84, 0.08);
}

/* ---------------------------------------------------------------------
   Reveal reset / deterministic export canvas
   --------------------------------------------------------------------- */
.reveal .controls,
.reveal .progress,
.reveal .slide-number,
.reveal .slide-logo,
.reveal .footer,
.reveal .slide-footer,
.reveal .speaker-notes,
.slide-menu-button,
#slide-menu-button,
#quarto-log-error-modal {
  display: none !important;
  visibility: hidden !important;
  opacity: 0 !important;
}

html, body, .reveal {
  margin: 0 !important;
  padding: 0 !important;
  background: #ffffff !important;
  overflow: hidden !important;
  -webkit-font-smoothing: antialiased;
}

.reveal .slides section.lvd-transition-slide,
.reveal .slides section.lvd-standard-slide {
  padding: 0 !important;
  margin: 0 !important;
  width: 1600px !important;
  height: 900px !important;
  overflow: hidden !important;
  background: #ffffff !important;
}

.reveal .slides section.lvd-transition-slide > h2,
.reveal .slides section.lvd-standard-slide > h2 {
  display: none !important;
}

.reveal {
  color: var(--lvd-ink);
  font-family: "Avenir Next", "Aptos", "Segoe UI", Arial, system-ui, sans-serif;
  font-weight: 400;
}

.reveal strong { font-weight: 760; }
.reveal em { font-style: italic; }
.reveal p { margin: 0; }
.reveal .fragment { transition: none !important; }

/* ---------------------------------------------------------------------
   Shared shells
   --------------------------------------------------------------------- */
.lvd-shell,
.lvd-transition {
  position: relative;
  width: 1600px;
  height: 900px;
  margin: 0;
  padding: 0;
  overflow: hidden;
  box-sizing: border-box;
  font-family: "Avenir Next", "Aptos", "Segoe UI", Arial, system-ui, sans-serif;
}

.paper-slide { background: var(--lvd-paper); color: var(--lvd-ink); }
.thin-navy-rule { position: absolute; top: 18px; left: 28px; right: 28px; height: 12px; background: var(--lvd-navy); border-radius: 1px; }
.lvd-content { position: absolute; z-index: 2; top: 168px; left: 58px; right: 58px; bottom: 58px; box-sizing: border-box; }
.lvd-content.full-top { top: 58px; left: 58px; right: 58px; bottom: 62px; }

.lvd-reference {
  position: absolute;
  left: 92px;
  right: 92px;
  bottom: 30px;
  color: #7a8492;
  font-size: 10px;
  line-height: 1.15;
  text-align: center;
  z-index: 20;
}
.signal-kicker,
.panel-kicker,
.mini-kicker {
  color: var(--lvd-coral);
  font-size: 18px;
  font-weight: 820;
  letter-spacing: 0.10em;
  text-transform: uppercase;
}

.slide-big-title,
.signal-title,
.ars-title {
  color: var(--lvd-navy);
  font-size: 43px;
  line-height: 1.04;
  font-weight: 820;
  letter-spacing: -0.04em;
  margin-top: 14px;
}
.slide-big-title.small-title { font-size: 37px; letter-spacing: -0.035em; }
.slide-subtitle,
.ars-subtitle {
  margin-top: 12px;
  color: var(--lvd-navy);
  font-size: 24px;
  line-height: 1.2;
  font-weight: 700;
}
.bottom-line {
  position: absolute;
  left: 0;
  right: 0;
  bottom: 42px;
  min-height: 52px;
  padding: 15px 24px 12px 32px;
  border: 1px solid #ccd6e6;
  border-left: 12px solid var(--lvd-teal);
  border-radius: 8px;
  background: #eef2f7;
  color: var(--lvd-navy);
  font-size: 20px;
  line-height: 1.15;
  box-sizing: border-box;
}
.divider { height: 2px; background: #d8dee8; margin: 20px 0; }
.gold-line { background: #d6bd78 !important; }
.teal-text { color: var(--lvd-teal-dark) !important; }
.red-text { color: var(--lvd-coral-dark) !important; }
.cobalt-text { color: var(--lvd-cobalt) !important; }
.strong { font-weight: 780; }
.muted-line { color: var(--lvd-muted); font-size: 15px; margin: 4px 0 16px; }
.side-title { color: var(--lvd-navy); font-size: 30px; line-height: 1.04; font-weight: 790; letter-spacing: -0.025em; }

.panel-rule { position: absolute; top: 0; left: 0; right: 0; height: 12px; }
.panel-rule.teal, .teal .signal-card-rule { background: var(--lvd-teal); }
.panel-rule.coral, .coral .signal-card-rule { background: var(--lvd-coral); }
.panel-rule.gold, .gold .signal-card-rule { background: var(--lvd-sand); }
.panel-rule.cobalt, .cobalt .signal-card-rule { background: var(--lvd-cobalt); }

/* =====================================================================
   LVD STANDARD BACKDROP — THICK BANNER MATCHED TO THE CSCC DECK
   Used by all .lvd-banner-slide slides

   Title sizing system:
   - default:       60px / 760 weight
   - compact-title: 54px
   - small-title:   48px
   ===================================================================== */

.lvd-topbar,
.lvd-shell.lvd-banner-slide .lvd-topbar,
.lvd-shell .lvd-topbar {
  position: absolute !important;
  z-index: 10 !important;
  top: 0 !important;
  left: 0 !important;
  right: 0 !important;
  height: 145px !important;
  padding: 0 64px !important;
  box-sizing: border-box !important;
  display: flex !important;
  align-items: center !important;
  background: #293962 !important;
}

.lvd-topbar-title,
.lvd-shell.lvd-banner-slide .lvd-topbar-title,
.lvd-shell .lvd-topbar-title {
  margin: 0 !important;
  color: #ffffff !important;
  font-size: 60px !important;
  line-height: 0.98 !important;
  font-weight: 760 !important;
  letter-spacing: -0.035em !important;
}

.lvd-banner-slide.compact-title .lvd-topbar-title,
.lvd-shell.lvd-banner-slide.compact-title .lvd-topbar-title,
.lvd-shell.compact-title .lvd-topbar-title {
  font-size: 54px !important;
  line-height: 0.99 !important;
}

.lvd-banner-slide.small-title .lvd-topbar-title,
.lvd-shell.lvd-banner-slide.small-title .lvd-topbar-title,
.lvd-shell.small-title .lvd-topbar-title {
  font-size: 48px !important;
  line-height: 1.00 !important;
}

.lvd-banner-slide .lvd-content,
.lvd-shell.lvd-banner-slide .lvd-content,
.lvd-shell .lvd-content:not(.full-top) {
  top: 168px !important;
  left: 58px !important;
  right: 58px !important;
  bottom: 58px !important;
}

.lvd-banner-slide .signal-kicker { margin-top: 0; }
.lvd-banner-slide .slide-subtitle { margin-top: 4px; }

.lvd-banner-slide .signal-card-grid { margin-top: 28px; }
.lvd-banner-slide .signal-card { min-height: 280px; padding-top: 32px; padding-bottom: 28px; }
.lvd-banner-slide .signal-bottom { margin-top: 24px; }

.lvd-banner-slide .failed-grid,
.lvd-banner-slide .question-split,
.lvd-banner-slide .validation-grid,
.lvd-banner-slide .integration-timeline,
.lvd-banner-slide .cm-grid,
.lvd-banner-slide .rp1-grid,
.lvd-banner-slide .mechanism-flow,
.lvd-banner-slide .reg-flow,
.lvd-banner-slide .takehome-grid {
  margin-top: 18px;
}

.lvd-banner-slide .lvd-reference {
  bottom: 28px;
  font-size: 9px;
}

/* Guard against stale thin-rule/no-topbar markup. */
.lvd-shell.no-topbar .thin-navy-rule,
.thin-navy-rule { display: none !important; }

.lvd-shell.no-topbar,
.lvd-shell.paper-slide { background: #ffffff !important; }

/* ---------------------------------------------------------------------
   Slide 01 — Three melanoma updates that matter in 2026
   --------------------------------------------------------------------- */
.signal-title { font-size: 62px; margin-top: 20px; }
.signal-card-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 26px; margin-top: 52px; }
.signal-card {
  position: relative;
  min-height: 310px;
  padding: 40px 42px 34px;
  border: 1px solid var(--lvd-border);
  border-radius: 10px;
  background: var(--lvd-white);
  box-shadow: var(--shadow);
  overflow: hidden;
}
.signal-card-rule { position: absolute; top: 0; left: 0; right: 0; height: 12px; }
.signal-number { color: var(--lvd-sand-dark); font-size: 50px; font-weight: 840; line-height: 1; }
.signal-card-title {
  margin-top: 26px;
  color: var(--lvd-navy-dark);
  font-size: 38px;
  line-height: 1.07;
  font-weight: 820;
  letter-spacing: -0.04em;

  min-height: 82px;
}

.signal-card-text {
  margin-top: 20px;
  color: #4a556a;
  font-size: 22px;
  line-height: 1.20;
}
.signal-bottom {
  display: flex;
  align-items: center;
  gap: 44px;
  position: absolute;
  left: 0; right: 0; bottom: 62px;
  min-height: 96px;
  padding: 18px 34px;
  border-radius: 12px;
  background: linear-gradient(90deg, #c99537 0 132px, #062463 132px 100%);
  color: #ffffff;
  font-size: 32px;
  line-height: 1.10;
  font-weight: 790;
  letter-spacing: -0.02em;
  box-shadow: var(--shadow-soft);
}
.signal-clock {
  width: 96px;
  height: 96px;
  margin-left: -14px;
  flex: 0 0 auto;
  overflow: visible;
  filter: drop-shadow(0 8px 14px rgba(0,0,0,0.15));
}
.signal-clock .clock-face {
  fill: none;
  stroke: #ffffff;
  stroke-width: 6;
}
.signal-clock .clock-ticks line {
  stroke: #ffffff;
  stroke-width: 5;
  stroke-linecap: round;
  opacity: 0.95;
}
.signal-clock .clock-hand {
  stroke: #ffffff;
  stroke-width: 7;
  stroke-linecap: round;
}
.signal-clock .clock-hand.hour { stroke-width: 7.5; }
.signal-clock .clock-hand.minute { stroke-width: 7.5; }
.signal-clock .clock-pivot {
  fill: #ffffff;
  stroke: rgba(255,255,255,0.55);
  stroke-width: 3;
}

/* ---------------------------------------------------------------------
   Slide 02 / 08 / 10 — Section break slides
   --------------------------------------------------------------------- */
.lvd-transition {
  background: radial-gradient(circle at 84% 14%, rgba(217,185,120,0.20), transparent 30%), linear-gradient(135deg, #18233f, #28365f 62%, #344776);
  color: #fff;
}
.lvd-transition.transition-melanoma { background: radial-gradient(circle at 82% 15%, rgba(217,185,120,0.20), transparent 30%), linear-gradient(135deg, #18233f, #28365f 62%, #344776); }
.lvd-transition.transition-cobalt { background: radial-gradient(circle at 82% 15%, rgba(46,132,131,0.16), transparent 30%), linear-gradient(135deg, #142d5c, #28365f 62%, #4058b3); }
.lvd-transition.transition-coral { background: radial-gradient(circle at 82% 15%, rgba(217,185,120,0.16), transparent 30%), linear-gradient(135deg, #3a1f2d, #633049 56%, #a9534d); }
.transition-wrap { position: absolute; left: 78px; top: 155px; width: 1100px; }
.transition-index { color: var(--lvd-sand); font-size: 40px; line-height: 1; font-weight: 840; letter-spacing: 0.06em; }
.transition-kicker { margin-top: 32px; color: var(--lvd-sand); font-size: 22px; font-weight: 840; letter-spacing: 0.13em; text-transform: uppercase; }
.transition-title { max-width: 1180px; margin-top: 34px; color: #fff; font-size: 67px; line-height: 1.10; font-weight: 800; letter-spacing: -0.045em; }
.transition-subtitle { max-width: 1140px; margin-top: 34px; color: rgba(255,255,255,0.80); font-size: 32px; line-height: 1.25; }
.transition-brand { position: absolute; right: 92px; bottom: 72px; color: rgba(255,255,255,0.78); font-size: 13px; font-weight: 750; }
.transition-dots { position: absolute; right: 130px; top: 78px; width: 360px; height: 330px; opacity: 0.82; background-image: radial-gradient(circle, #2e8483 0 7px, transparent 8px), radial-gradient(circle, #d9b978 0 8px, transparent 9px), radial-gradient(circle, #d9b978 0 11px, transparent 12px); background-size: 96px 86px, 118px 104px, 150px 130px; background-position: 0 0, 34px 22px, 80px 58px; }


/* ---------------------------------------------------------------------
   Slide 03 — MERLIN_001 study design
   QMD: ## What was MERLIN_001? {.merlin-design-slide}
   --------------------------------------------------------------------- */

.merlin-design-slide .lvd-content {
  top: 168px !important;
  left: 58px !important;
  right: 58px !important;
  bottom: 128px !important;
}


/* Study framing ------------------------------------------------------ */

.merlin-design-slide .slide-subtitle {
  margin-top: 4px;
  font-size: 25px;
  line-height: 1.14;
}


/* Main layout -------------------------------------------------------- */

.merlin-design-slide .design-grid {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 370px;
  gap: 26px;
  margin-top: 20px;
  height: 505px;
}


/* Main workflow panel ----------------------------------------------- */

.merlin-design-slide .design-main {
  position: relative;
  min-height: 0;
  height: 505px;
  box-sizing: border-box;

  border: 1px solid var(--lvd-border);
  border-top: 10px solid var(--lvd-teal);
  border-radius: 10px;

  background: #fff;
  padding: 26px 24px 22px;
  box-shadow: var(--shadow-soft);
}

.merlin-design-slide .design-kicker {
  color: var(--lvd-navy);
  font-size: 30px;
  line-height: 1.03;
  font-weight: 800;
}

.merlin-design-slide .design-caption {
  margin-top: 6px;

  color: var(--lvd-muted);
  font-size: 20px;
  line-height: 1.12;
}


/* Four-step workflow ------------------------------------------------ */

.merlin-design-slide .workflow-row {
  display: grid;

  grid-template-columns:
    minmax(0, 1fr) 16px
    minmax(0, 1fr) 16px
    minmax(0, 1fr) 16px
    minmax(0, 1fr);

  gap: 4px;
  align-items: center;
  margin-top: 26px;
}

.merlin-design-slide .workflow-step {
  min-width: 0;
  height: 184px;
  min-height: 184px;
  box-sizing: border-box;

  border: 1px solid var(--lvd-border);
  border-radius: 9px;

  background: #fff;
  padding: 18px 16px 14px;

  box-shadow: 0 6px 12px rgba(34,48,84,0.06);
}

.merlin-design-slide .workflow-step span {
  display: inline-flex;
  align-items: center;
  justify-content: center;

  width: 42px;
  height: 42px;

  margin-top: -18px;
  margin-right: 8px;
  margin-bottom: 1px;

  border-radius: 50%;

  background: var(--lvd-coral);
  color: #fff;

  font-size: 18px;
  font-weight: 800;
}

.merlin-design-slide .workflow-step:nth-of-type(3) span {
  background: var(--lvd-teal);
}

.merlin-design-slide .workflow-step:nth-of-type(5) span {
  background: var(--lvd-sand-dark);
}

.merlin-design-slide .workflow-step:nth-of-type(7) span {
  background: var(--lvd-cobalt);
}

.merlin-design-slide .workflow-step strong {
  color: var(--lvd-navy);

  font-size: 23px;
  line-height: 1.02;
  font-weight: 800;

  white-space: nowrap;
}

.merlin-design-slide .workflow-step p {
  margin-top: 10px;
  margin-bottom: 1px;

  color: var(--lvd-ink);
  font-size: 18px;
  line-height: 1.08;
}

.merlin-design-slide .workflow-step b {
  display: inline-block;

  margin-bottom: 6px;

  font-weight: 800;
}

.merlin-design-slide .workflow-arrow {
  color: var(--lvd-sand-dark);

  font-size: 32px;
  line-height: 1;
  font-weight: 800;

  text-align: center;
}


/* Three explanatory cards ------------------------------------------ */

.merlin-design-slide .design-mini-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));

  gap: 18px;
  margin-top: 30px;
}

.merlin-design-slide .design-mini-card {
  height: 132px;
  min-height: 132px;
  box-sizing: border-box;

  border: 1px solid var(--lvd-border);
  border-radius: 10px;

  padding: 18px 20px;
}

.merlin-design-slide .design-mini-card.sand {
  background: var(--lvd-soft-sand);
  border-color: #e1d0a5;
}

.merlin-design-slide .design-mini-card.mint {
  background: var(--lvd-soft-teal);
  border-color: #bddcd7;
}

.merlin-design-slide .design-mini-card.coral-soft {
  background: var(--lvd-soft-coral);
  border-color: #e7c9c3;
}

.merlin-design-slide .design-mini-card strong {
  display: block;

  margin-bottom: 9px;

  color: var(--lvd-navy);
  font-size: 26px;
  line-height: 1.02;
}

.merlin-design-slide .design-mini-card p {
  color: var(--lvd-ink);

  font-size: 17.5px;
  line-height: 1.09;
}


/* Design facts panel ----------------------------------------------- */

.merlin-design-slide .design-side {
  min-height: 0;
  height: 505px;
  box-sizing: border-box;

  border: 1px solid #e0d1a9;
  border-top: 10px solid var(--lvd-sand);
  border-radius: 10px;

  background: var(--lvd-soft-sand);

  padding: 26px 24px 20px;

  box-shadow: var(--shadow-soft);
}

.merlin-design-slide .design-side .side-title {
  font-size: 31px;
  line-height: 1.02;
}

.merlin-design-slide .side-fact {
  display: grid;
  grid-template-columns: 110px minmax(0, 1fr);

  gap: 12px;
  align-items: start;

  margin-top: 14px;
  padding: 14px;

  border: 1px solid #e3d6b8;
  border-radius: 8px;

  background: #fff;
}

.merlin-design-slide .side-fact span {
  color: var(--lvd-sand-dark);

  font-size: 18px;
  line-height: 1.04;
  font-weight: 780;
}

.merlin-design-slide .side-fact strong {
  color: var(--lvd-ink);

  font-size: 16.5px;
  line-height: 1.08;
}


/* Bottom-line takeaway --------------------------------------------- */

.merlin-design-slide .merlin-bottom-line {
  position: absolute;

  left: 58px;
  right: 58px;
  bottom: 70px;

  min-height: 56px;
  box-sizing: border-box;

  padding: 14px 28px 12px 32px;

  border: 1px solid #ccd6e6;
  border-left: 10px solid var(--lvd-teal);
  border-radius: 8px;

  background: #eef2f7;
  color: var(--lvd-navy);

  font-size: 20px;
  line-height: 1.15;

  z-index: 30;
}


/* Citation / legal ------------------------------------------------- */

.merlin-design-slide .lvd-reference {
  bottom: 25px;
  font-size: 9px;
}


/* ---------------------------------------------------------------------
   Slide 04 — MERLIN_001 missed primary endpoint
   QMD: ## MERLIN_001 missed its primary endpoint. Did the study still matter?
   --------------------------------------------------------------------- */

.merlin-failed-slide .failed-grid {
  display: grid;
  grid-template-columns: 1fr 1.08fr;
  gap: 42px;
  margin-top: 40px;
}

.merlin-failed-slide .failed-left,
.merlin-failed-slide .failed-right {
  position: relative;
  min-height: 400px;
  border-radius: 10px;
  border: 1px solid var(--lvd-border);
  background: #fff;
  box-shadow: var(--shadow-soft);
  padding: 36px 42px 28px;  /* slightly tighter vertically */
  overflow: hidden;
}



.merlin-failed-slide .failed-grid {
  margin-top: 40px;
}



.merlin-failed-slide .failed-grid {
  display: grid;
  grid-template-columns: 1fr 1.08fr;
  gap: 42px;
  margin-top: 28px;
}

.merlin-failed-slide .failed-left,
.merlin-failed-slide .failed-right {
  position: relative;
  min-height: 410px;
  border-radius: 10px;
  border: 1px solid var(--lvd-border);
  background: #fff;
  box-shadow: var(--shadow-soft);
  padding: 36px 42px 28px;
  overflow: hidden;
}


/* ========================================================================
   LVD 2026 — MELANOMA UPDATES FOR THE DERMATOLOGIST
   Quarto / Reveal.js design system
   Source of truth for HTML → PNG → PowerPoint export

   Organization follows the QMD slide order:
   00 global/reset → 01 three updates → 02 section break →
   03 MERLIN design → 04 missed endpoint → 05 question reframing →
   06 MERLIN validation → 07 MERLIN timeline/integration → 08 section break →
   09 CheckMate 067 → 10 section break → 11–13 RP1 → 14 take-home
   ======================================================================== */

:root {
  --lvd-navy: #28365f;
  --lvd-navy-dark: #18233f;
  --lvd-cobalt: #4058b3;
  --lvd-cobalt-bright: #526bc8;
  --lvd-teal: #2e8483;
  --lvd-teal-dark: #226b6c;
  --lvd-coral: #c96f61;
  --lvd-coral-dark: #a9534d;
  --lvd-sand: #d9b978;
  --lvd-sand-dark: #b8924f;
  --lvd-ink: #1d2943;
  --lvd-muted: #68717d;
  --lvd-paper: #fbfaf7;
  --lvd-white: #ffffff;
  -
  overflow: hidden;
}

.merlin-failed-slide .failed-right {
  background: var(--lvd-soft-sand);
  border-color: #ddc98a;
}

.merlin-failed-slide .objective-row {
  display: grid;
  grid-template-columns: 1fr 150px;
  gap: 20px;
  align-items: center;
  margin-top: 24px;
}

.merlin-failed-slide .objective-row strong {
  color: var(--lvd-navy);
  font-size: 21px;
}

.merlin-failed-slide .objective-row p {
  margin-top: 24px;
  color: var(--lvd-ink);
  font-size: 29px;
  line-height: 1.18;
}

.merlin-failed-slide .big-target {
  font-size: 56px;
  font-weight: 840;
  line-height: 1;
  text-align: center;
}

.merlin-failed-slide .objective-row.observed {
  margin-top: 18px;
}

.merlin-failed-slide .endpoint-badge {
  display: inline-block;
  margin-top: 18px;
  padding: 13px 28px;
  border-radius: 16px;
  background: #f7e8e3;
  color: var(--lvd-coral-dark);
  font-size: 16px;
  font-weight: 820;
  text-transform: uppercase;
}

.merlin-failed-slide .failed-caption {
  margin-top: 28px;
  color: var(--lvd-ink);
  font-size: 24px;
  line-height: 1.18;
}

.merlin-failed-slide .metric-list {
  margin-top: 36px;
}

.merlin-failed-slide .metric-list div {
  display: grid;
  grid-template-columns: 160px 1fr;
  gap: 18px;
  align-items: center;
  margin: 31px 0;
}

.merlin-failed-slide .metric-list strong {
  color: var(--lvd-teal-dark);
  font-size: 42px;
  line-height: 1;
}

.merlin-failed-slide .metric-list span {
  color: var(--lvd-ink);
  font-size: 28px;
}

.merlin-failed-slide .right-bottom-statement {
  color: var(--lvd-sand-dark);
  font-size: 26px;
  line-height: 1.12;
  font-weight: 770;
}

/* Slide-specific takeaway bar.
   This sits OUTSIDE .lvd-content, so bottom is measured from the slide shell. */
.merlin-failed-slide .merlin-failed-bottom {
  position: absolute;
  left: 58px;
  right: 58px;
  bottom: 35px;

  min-height: 60px;
  padding: 14px 20px 12px 24px;

  border: 1px solid #ccd6e6;
  border-left: 10px solid var(--lvd-teal);
  border-radius: 8px;

  background: #eef2f7;
  color: var(--lvd-navy);

  font-size: 20px;
  line-height: 1.0;

  box-sizing: border-box;
  z-index: 30;
}

/* Citation remains independently pinned to the shell bottom. */
.merlin-failed-slide .lvd-reference {
  bottom: 25px;
  font-size: 9px;
}


/* ---------------------------------------------------------------------
   Slide 05 — MERLIN question reframing
   --------------------------------------------------------------------- */
.question-split { display: grid; grid-template-columns: 1fr 150px 1fr; align-items: center; gap: 24px; margin-top: 58px; }
.question-card { min-height: 390px; border-radius: 10px; padding: 34px 38px; border: 1px solid var(--lvd-border); background: #fff; box-shadow: var(--shadow-soft); }
.question-card.no { background: var(--lvd-soft-coral); border-color: #e7c9c3; }
.question-card.yes { background: var(--lvd-soft-teal); border-color: #bddcd7; }
.question-label { 
  display: inline-block; padding: 7px 13px; border-radius: 999px; background: #fff; color: var(--lvd-sand-dark); 
  font-size: 20px; font-weight: 820; text-transform: uppercase; }
.question-title { margin-top: 24px; color: var(--lvd-navy); font-size: 30px; line-height: 1.12; font-weight: 780; }
.answer-label { margin-top: 36px; color: var(--lvd-muted); font-size: 22px; font-weight: 820; text-transform: uppercase; }
.answer-large { margin-top: 8px; font-size: 30px; font-weight: 820; }
.question-card p { margin-top: 20px; font-size: 24px; line-height: 1.20; color: var(--lvd-ink); }
.reframe-arrow { 
  display: flex; 
  align-items: center; 
  justify-content: center; 
  height: 120px; 
  color: #fff; 
  background: var(--lvd-sand); 
  clip-path: polygon(0 0, 72% 0, 100% 50%, 72% 100%, 0 100%, 14% 50%); 
  font-size: 17px; 
  font-weight: 820; 
  text-transform: uppercase; 
  letter-spacing: 0.04em; 
  
}
.merlin-question-slide .merlin-question-bottom {
  font-size: 24px;
  line-height: 1.14;
}

/* ---------------------------------------------------------------------
   Slide 06 — MERLIN validation
   QMD: ## MERLIN_001: the signal is strongest where the decision is hardest.
   --------------------------------------------------------------------- */

.merlin-validation-slide .validation-grid {
  display: grid;
  grid-template-columns: 1fr 420px;
  gap: 44px;
  margin-top: 34px;
}

.merlin-validation-slide .validation-left {
  min-width: 0;
}

.merlin-validation-slide .stat-row {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 30px;
}

/* Bigger, centered stat cards */
.merlin-validation-slide .stat-tile {
  min-height: 165px;
  box-sizing: border-box;

  display: flex;
  flex-direction: column;
  align-items: center;
  justify-content: center;

  padding: 22px 24px;

  border: 1px solid var(--lvd-border);
  border-radius: 9px;
  background: #fff;
  text-align: center;
  box-shadow: var(--shadow-soft);
}

.merlin-validation-slide .stat-tile.mint {
  background: var(--lvd-soft-teal);
  border-color: #bddcd7;
}

.merlin-validation-slide .stat-tile strong {
  display: block;
  color: var(--lvd-navy);
  font-size: 54px;
  line-height: 0.95;
  font-weight: 840;
}

.merlin-validation-slide .stat-tile.mint strong {
  color: var(--lvd-teal-dark);
}

.merlin-validation-slide .stat-tile span {
  display: block;
  margin-top: 18px;

  color: var(--lvd-muted);
  font-size: 19px;
  line-height: 1.12;
  font-weight: 700;
}

/* Bar card moved down for better visual hierarchy */
.merlin-validation-slide .bars-card {
  margin-top: 65px;
  padding: 28px 30px;

  border: 1px solid var(--lvd-border);
  border-radius: 10px;
  background: #fff;
  box-shadow: var(--shadow-soft);
}

.merlin-validation-slide .bars-title {
  color: var(--lvd-navy);
  font-size: 27px;
  line-height: 1.12;
  font-weight: 790;
  margin-bottom: 28px;
}

.merlin-validation-slide .bar-row {
  display: grid;
  grid-template-columns: 44px 1fr 90px;
  gap: 18px;
  align-items: center;
  margin: 20px 0;
}

.merlin-validation-slide .bar-row span {
  color: var(--lvd-muted);
  font-size: 20px;
  font-weight: 760;
}

.merlin-validation-slide .bar-row strong {
  color: var(--lvd-navy);
  font-size: 21px;
}

.merlin-validation-slide .bar-bg {
  height: 34px;
  background: #eef1f6;
  border: 1px solid #d6ddea;
}

.merlin-validation-slide .bar-bg div {
  height: 100%;
  background: var(--lvd-teal);
}

.merlin-validation-slide .bar-note {
  margin-top: 24px;
  color: var(--lvd-muted);
  font-size: 16px;
}

/* Right explanatory panel */
.merlin-validation-slide .validation-side {
  min-height: 450px;
  box-sizing: border-box;

  border: 1px solid #e0d1a9;
  border-radius: 10px;
  background: var(--lvd-soft-sand);

  padding: 42px 38px;
  box-shadow: var(--shadow-soft);
}

.merlin-validation-slide .validation-side .risk-zone {
  margin-top: 46px;
  color: var(--lvd-sand-dark);
  font-size: 28px;
  font-weight: 820;
}

.merlin-validation-slide .validation-side p {
  margin-top: 18px;
  color: var(--lvd-ink);
  font-size: 24px;
  line-height: 1.22;
}

.merlin-validation-slide .validation-side .strong {
  font-size: 28px;
  line-height: 1.2;
}

/* Slide-specific takeaway bar.
   This sits outside .lvd-content, so bottom is measured from the slide shell. */
.merlin-validation-slide .merlin-validation-bottom {
  position: absolute;
  left: 58px;
  right: 58px;
  bottom: 45px;

  min-height: 56px;
  padding: 14px 28px 12px 32px;

  border: 1px solid #ccd6e6;
  border-left: 10px solid var(--lvd-teal);
  border-radius: 8px;

  background: #eef2f7;
  color: var(--lvd-navy);

  font-size: 21px;
  line-height: 1.14;

  box-sizing: border-box;
  z-index: 30;
}

.merlin-validation-slide .lvd-reference {
  bottom: 25px;
  font-size: 9px;
}


/* ---------------------------------------------------------------------
   Slide 07 — FAILED Endpoint
   --------------------------------------------------------------------- */
.evolution-row { display: grid; grid-template-columns: 1fr 56px 1fr 56px 1fr; align-items: center; gap: 18px; margin-top: 54px; }
.evolution-card { min-height: 395px; padding: 28px 30px; background: #fff; border: 2px solid var(--lvd-coral); border-radius: 10px; box-shadow: var(--shadow-soft); }
.evolution-card.cobalt-border { border-color: var(--lvd-cobalt); }
.evolution-card.teal-border { border-color: var(--lvd-teal); }
.year { display: inline-block; padding: 8px 12px; border-radius: 999px; background: #fff7ec; color: var(--lvd-sand-dark); font-size: 20px; font-weight: 840; }
.evolution-title { margin-top: 20px; color: var(--lvd-navy); font-size: 28px; font-weight: 800; line-height: 1.08; }
.big-value { margin-top: 10px; font-size: 42px; line-height: 1; font-weight: 840; }
.evolution-card p { margin-top: 18px; color: var(--lvd-ink); font-size: 22px; line-height: 1.22; }
.evolution-card small { display: block; margin-top: 18px; color: var(--lvd-muted); font-size: 18px; line-height: 1.18; font-weight: 650; }
.evolution-arrow { text-align: center; color: var(--lvd-sand-dark); font-size: 52px; font-weight: 820; }

/* ---------------------------------------------------------------------
   Slide 08 — MERLIN clinical integration
   QMD: ## MERLIN matters only if it changes the SLNB decision

   Replace the prior MERLIN integration section with this entire block.
   This block uses new timeline-specific classes:
   .merlin-flow-panel, .merlin-flow, .merlin-flow-step, .merlin-flow-node

   Remove/ignore the old timeline classes for this slide:
   .integration-timeline, .timeline-line, .timeline-steps,
   .integration-bottom-grid
   --------------------------------------------------------------------- */

.merlin-integration-slide .lvd-content {
  top: 168px !important;
  left: 58px !important;
  right: 58px !important;
  bottom: 132px !important; /* protects bottom-line + reference */
}

.merlin-integration-slide .slide-subtitle {
  font-size: 25px;
  line-height: 1.14;
}

/* Workable timeline -------------------------------------------------- */

.merlin-integration-slide .merlin-flow-panel {
  position: relative;
  box-sizing: border-box;

  margin-top: 18px;
  min-height: 220px;      /* was 242px */
  padding: 20px 36px 18px; /* was 26px 36px 24px */

  border: 1px solid var(--lvd-border);
  border-top: 9px solid var(--lvd-teal);
  border-radius: 10px;
  background: #fff;
  box-shadow: var(--shadow-soft);
}

.merlin-integration-slide .merlin-flow-title {
  color: var(--lvd-navy);
  font-size: 31px;
  line-height: 1.04;
  font-weight: 830;
}

.merlin-integration-slide .merlin-flow-subtitle {
  margin-top: 6px;
  color: var(--lvd-muted);
  font-size: 18px;
  line-height: 1.14;
}

.merlin-integration-slide .merlin-flow {
  position: relative;

  display: grid;
  grid-template-columns: repeat(5, minmax(0, 1fr));
  gap: 0;

  margin-top: 28px;
  padding: 0 36px;
}

.merlin-integration-slide .merlin-flow::before {
  content: "";
  position: absolute;

  left: calc(10% + 36px);
  right: calc(10% + 36px);
  top: 25px;

  height: 4px;
  background: #d8c182;
  z-index: 0;
}

.merlin-integration-slide .merlin-flow-step {
  position: relative;
  z-index: 1;

  min-width: 0;
  text-align: center;
}

.merlin-integration-slide .merlin-flow-node {
  display: flex;
  align-items: center;
  justify-content: center;

  width: 50px;
  height: 50px;
  margin: 0 auto 14px;

  border-radius: 50%;
  color: #fff;

  font-size: 18px;
  line-height: 1;
  font-weight: 850;

  box-shadow: 0 4px 8px rgba(34,48,84,0.12);
}

.merlin-integration-slide .merlin-flow-node.coral { background: var(--lvd-coral); }
.merlin-integration-slide .merlin-flow-node.gold { background: var(--lvd-sand-dark); }
.merlin-integration-slide .merlin-flow-node.teal { background: var(--lvd-teal); }
.merlin-integration-slide .merlin-flow-node.cobalt { background: var(--lvd-cobalt); }

.merlin-integration-slide .merlin-flow-step strong {
  display: block;

  color: var(--lvd-navy);
  font-size: 20px;
  line-height: 1.04;
  font-weight: 830;
}

.merlin-integration-slide .merlin-flow-step p {
  max-width: 205px;
  margin: 7px auto 0;

  color: var(--lvd-ink);
  font-size: 15px;
  line-height: 1.14;
}

/* Lower operational panels ------------------------------------------ */

.merlin-integration-slide .merlin-integration-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 34px;

  margin-top: 8px;
}

.merlin-integration-slide .owner-panel,
.merlin-integration-slide .ops-panel {
  position: relative;
  box-sizing: border-box;

  min-height: 210px;
  padding: 22px 32px 16px;

  border: 1px solid var(--lvd-border);
  border-radius: 10px;
  background: #fff;
  box-shadow: var(--shadow-soft);
  overflow: hidden;
}

.merlin-integration-slide .ops-panel {
  background: var(--lvd-soft-sand);
  border-color: #e0d1a9;
}

.merlin-integration-slide .owner-panel .side-title,
.merlin-integration-slide .ops-panel .side-title {
  font-size: 30px;
  line-height: 1.03;
}

.merlin-integration-slide .owner-panel .muted-line,
.merlin-integration-slide .ops-panel .muted-line {
  margin: 4px 0 10px;
  font-size: 15px;
  line-height: 1.10;
}

.merlin-integration-slide .owner-row,
.merlin-integration-slide .ops-row {
  display: grid;
  grid-template-columns: 170px minmax(0, 1fr);
  gap: 18px;
  align-items: start;

  margin-top: 8px;
  padding: 9px 10px;

  border: 1px solid #e3e8ef;
  border-radius: 6px;
  background: #f8fafc;
}

.merlin-integration-slide .owner-row strong,
.merlin-integration-slide .ops-row strong {
  color: var(--lvd-sand-dark);
  font-size: 16px;
  line-height: 1.05;
  font-weight: 830;
}

.merlin-integration-slide .owner-row span,
.merlin-integration-slide .ops-row span {
  color: var(--lvd-ink);
  font-size: 15.5px;
  line-height: 1.14;
}

.merlin-integration-slide .owner-row.coral {
  border-left: 7px solid var(--lvd-coral);
}

.merlin-integration-slide .owner-row.teal {
  border-left: 7px solid var(--lvd-teal);
}

.merlin-integration-slide .owner-row.navy {
  border-left: 7px solid var(--lvd-navy);
}

.merlin-integration-slide .owner-row.coral strong {
  color: var(--lvd-coral);
}

.merlin-integration-slide .owner-row.teal strong {
  color: var(--lvd-teal);
}

.merlin-integration-slide .owner-row.navy strong {
  color: var(--lvd-navy);
}

/* Bottom-line takeaway ---------------------------------------------- */

.merlin-integration-slide .merlin-integration-bottom {
  position: absolute;

  left: 58px;
  right: 58px;
  bottom: 36px;

  min-height: 58px;
  box-sizing: border-box;

  padding: 15px 28px 12px 32px;

  border: 1px solid #ccd6e6;
  border-left: 10px solid var(--lvd-teal);
  border-radius: 8px;

  background: #eef2f7;
  color: var(--lvd-navy);

  font-size: 22px;
  line-height: 1.14;

  z-index: 30;
}

.merlin-integration-slide .lvd-reference {
  bottom: 25px;
  font-size: 9px;
}




.owner-panel, .ops-panel { position: relative; min-height: 245px; padding: 30px 32px 22px; border: 1px solid var(--lvd-border); border-radius: 10px; background: #fff; box-shadow: var(--shadow-soft); overflow: hidden; }
.ops-panel { background: var(--lvd-soft-sand); border-color: #e0d1a9; }
.owner-row, .ops-row { display: grid; grid-template-columns: 180px 1fr; gap: 18px; align-items: start; padding: 9px 10px; margin-top: 8px; border-radius: 6px; background: #f8fafc; border: 1px solid #e3e8ef; }
.owner-row strong, .ops-row strong { color: var(--lvd-sand-dark); font-size: 15px; }
.owner-row span, .ops-row span { color: var(--lvd-ink); font-size: 14px; line-height: 1.15; }
.owner-row.coral { border-left: 7px solid var(--lvd-coral); }
.owner-row.teal { border-left: 7px solid var(--lvd-teal); }
.owner-row.navy { border-left: 7px solid var(--lvd-navy); }
.owner-row.coral strong { color: var(--lvd-coral); }
.owner-row.teal strong { color: var(--lvd-teal); }
.owner-row.navy strong { color: var(--lvd-navy); }

/* ---------------------------------------------------------------------
   Slide 09 — CheckMate 067
   FULL REPLACEMENT of the existing Slide 09 CSS block
   --------------------------------------------------------------------- */

.cm067-slide .lvd-content {
  top: 168px !important;
  left: 58px !important;
  right: 58px !important;
  bottom: 128px !important; /* reserve space for bottom line + reference */
}

.cm067-slide .slide-subtitle {
  margin-top: 4px;
  font-size: 25px;
  line-height: 1.14;
}

.cm-grid {
  display: grid;
  grid-template-columns: 1.22fr 0.86fr;
  grid-template-rows: auto 1fr;
  gap: 22px;
  margin-top: 26px;
}

.cm-hero {
  grid-row: span 2;
  border-radius: 12px;
  background: linear-gradient(135deg, #1e2a50, #293962 62%, #4058b3);
  color: #ffffff;
  padding: 40px 42px 36px;
  box-shadow: var(--shadow);
}

.huge-percent {
  color: var(--lvd-sand);
  margin-top: 30px;
  margin-bottom: 20px;
  font-size: 110px;
  line-height: 0.84;
  font-weight: 860;
  letter-spacing: -0.055em;
}

.hero-text {
  margin-top: 16px;
  font-size: 32px;
  line-height: 1.08;
  font-weight: 800;
}

.hero-sub {
  margin-top: 30px;
  color: rgba(255,255,255,0.83);
  font-size: 29px;
  line-height: 1.12;
  font-weight: 560;
}

.cm-hero p {
  margin-top: 30px;
  color: rgba(255,255,255,0.84);
  font-size: 30px;
  line-height: 1.20;
}

.cm-table {
  border: 1px solid var(--lvd-border);
  border-top: 8px solid var(--lvd-cobalt);
  border-radius: 10px;
  background: #ffffff;
  padding: 18px 20px 12px;
  box-shadow: var(--shadow-soft);
}

.cm-table .side-title {
  color: var(--lvd-navy);
  font-size: 25px;
  line-height: 1.04;
  font-weight: 800;
  margin-bottom: 6px;
}

.cm-row {
  display: grid;
  grid-template-columns: 1fr 175px; /* was 140px */
  gap: 18px;
  align-items: center;
  padding: 12px 0;
  border-bottom: 1px solid #edf0f5;
}

.cm-row:last-child {
  border-bottom: none;
}

.cm-row span {
  color: var(--lvd-ink);
  font-size: 26px;
  line-height: 1.08;
}

.cm-row strong {
  color: var(--lvd-navy);
  font-size: 33px;
  line-height: 1;
  text-align: right;
  font-weight: 820;
  white-space: nowrap; /* NEW property in existing rule */
}

.cm-row.combo strong {
  color: var(--lvd-cobalt);
}

.cm-side-stack {
  display: grid;
  grid-template-rows: auto auto;
  gap: 1px;
  align-content: start;
}

.cm-side-card {
  border-radius: 10px;
  padding: 16px 18px;   /* was larger */
  border: 1px solid var(--lvd-border);
  box-shadow: var(--shadow-soft);
}

.cm-side-card.mint {
  background: var(--lvd-soft-teal);
  border-color: #bddcd7;
}

.cm-side-card.coral-soft {
  background: var(--lvd-soft-coral);
  border-color: #e7c9c3;
}

.side-metric {
  color: var(--lvd-teal-dark);
  font-size: 48px;
  line-height: 1;
  font-weight: 850;
}

.cm-side-card p {
  margin-top: 8px;      /* reduce this */
  color: var(--lvd-ink);
  font-size: 18px;
  line-height: 1.16;
}

.cm-side-card strong {
  display: block;
  margin-top: 10px;     /* reduce this */
  color: var(--lvd-coral-dark);
  font-size: 22px;
  line-height: 1.12;
}

.cm067-slide .cm067-bottom {
  position: absolute;
  left: 58px;
  right: 58px;
  bottom: 34px;
  min-height: 54px;
  padding: 12px 22px 11px 22px;
  border: 1px solid #ccd6e6;
  border-left: 8px solid var(--lvd-teal);
  border-radius: 8px;
  background: #eef2f7;
  color: var(--lvd-navy);
  font-size: 19px;
  line-height: 1.14;
  box-sizing: border-box;
  z-index: 30;
}

.cm067-slide .lvd-reference {
  bottom: 22px;
  font-size: 8.5px;
}


/* ---------------------------------------------------------------------
   Slides 11–13 — RP1
   --------------------------------------------------------------------- */
.rp1-grid { display: grid; grid-template-columns: 0.86fr 1.14fr; gap: 54px; margin-top: 54px; }
.indication-card { position: relative; min-height: 490px; padding: 48px 42px 36px; border: 1px solid #e7c9c3; border-radius: 10px; background: var(--lvd-soft-coral); box-shadow: var(--shadow-soft); overflow: hidden; }
.indication-card p { margin-top: 35px; color: var(--lvd-navy); font-size: 27px; line-height: 1.12; font-weight: 760; }
.indication-card small { display: block; margin-top: 28px; color: var(--lvd-muted); font-size: 17px; line-height: 1.18; }
.rp1-data { padding: 14px 0 0; }
.rp1-n { margin-top: 28px; color: var(--lvd-muted); font-size: 30px; font-weight: 780; }
.rp1-stat-row { display: grid; grid-template-columns: 1fr 1fr; gap: 44px; margin-top: 36px; }
.rp1-stat { min-height: 160px; border-radius: 10px; border: 1px solid var(--lvd-border); padding: 36px 30px; text-align: center; box-shadow: var(--shadow-soft); }
.rp1-stat.mint { background: var(--lvd-soft-teal); border-color: #bddcd7; }
.rp1-stat.sand { background: var(--lvd-soft-sand); border-color: #e0d1a9; }
.rp1-stat strong { display: block; color: var(--lvd-teal-dark); margin-top: 28px; font-size: 54px; line-height: 1; }
.rp1-stat.sand strong { color: var(--lvd-sand-dark); }
.rp1-stat span { display: block; margin-top: 28px; color: var(--lvd-navy); font-size: 23px; line-height: 1.12; font-weight: 760; }
.noninjected-note { margin-top: 32px; display: grid; grid-template-columns: 260px 1fr; gap: 32px; align-items: center; border: 1px solid var(--lvd-border); border-radius: 10px; background: #fff; padding: 24px 30px; }
.noninjected-note strong { color: var(--lvd-navy); font-size: 28px; line-height: 1.10; }
.noninjected-note span { color: var(--lvd-muted); font-size: 24px; line-height: 1.20; }
.mechanism-flow { display: grid; grid-template-columns: 1fr 54px 1fr 54px 1fr 54px 1fr; gap: 14px; align-items: center; margin-top: 74px; }
.mech-step { min-height: 210px; border-radius: 14px; background: #fff; border: 1px solid var(--lvd-border); padding: 32px 28px; box-shadow: var(--shadow); }
.mech-step span { display: flex; align-items: center; justify-content: center; width: 48px; height: 48px; border-radius: 50%; background: var(--lvd-teal); color: #fff; font-size: 20px; font-weight: 830; margin-bottom: 26px; }
.mech-step strong { color: var(--lvd-navy); font-size: 24px; line-height: 1.10; }
.mech-step p { margin-top: 15px; color: var(--lvd-muted); font-size: 18px; }
.mech-arrow { color: var(--lvd-sand-dark); font-size: 48px; text-align: center; font-weight: 830; }
.mechanism-bottom { display: grid; grid-template-columns: 0.9fr 1.1fr; gap: 34px; margin-top: 56px; }
.dose-card, .strategy-card { min-height: 166px; padding: 30px 34px; border: 1px solid var(--lvd-border); border-radius: 10px; background: #fff; box-shadow: var(--shadow-soft); }
.dose-card { background: var(--lvd-soft-sand); border-color: #e0d1a9; }
.dose-card p, .strategy-card p { margin-top: 18px; color: var(--lvd-ink); font-size: 20px; line-height: 1.22; }
.dose-card small { display: block; margin-top: 14px; color: var(--lvd-muted); font-size: 14px; }
.reg-flow { display: grid; grid-template-columns: 1fr 42px 1fr 42px 1fr 42px 1fr 42px 1fr; align-items: center; gap: 10px; margin-top: 68px; }
.reg-card { min-height: 185px; padding: 28px 24px; border-radius: 12px; background: #fff; border: 1px solid var(--lvd-border); box-shadow: var(--shadow-soft); }
.reg-card.coral-soft { background: var(--lvd-soft-coral); border-color: #e7c9c3; }
.reg-card.cobalt-soft { background: #f0f3ff; border-color: #cdd4ef; }
.reg-card.mint { background: var(--lvd-soft-teal); border-color: #bddcd7; }
.reg-card.sand { background: var(--lvd-soft-sand); border-color: #e0d1a9; }
.reg-card strong { color: var(--lvd-navy); font-size: 24px; line-height: 1.05; }
.reg-card p { margin-top: 16px; color: var(--lvd-ink); font-size: 16px; line-height: 1.16; }
.reg-arrow { text-align: center; color: var(--lvd-sand-dark); font-size: 42px; font-weight: 820; }
.reg-bottom-grid { display: grid; grid-template-columns: 1.2fr 0.8fr; gap: 34px; margin-top: 56px; }
.key-card { min-height: 154px; padding: 30px 34px; border-radius: 10px; border: 1px solid var(--lvd-border); background: #fff; box-shadow: var(--shadow-soft); }
.key-card p { margin-top: 18px; color: var(--lvd-ink); font-size: 20px; line-height: 1.20; }
.key-card.emphasis { background: var(--lvd-soft-sand); border-color: #e0d1a9; display: flex; align-items: center; }
.key-card.emphasis p { margin: 0; color: var(--lvd-sand-dark); font-size: 25px; line-height: 1.16; font-weight: 800; }

.rp1-approval-slide .rp1-derm-takeaway {
  position: absolute;

  left: 58px;
  right: 58px;
  bottom: 55px;

  min-height: 56px;
  padding: 14px 28px 12px 32px;

  font-size: 21px;
  line-height: 1.14;

  z-index: 30;
}

/* ---------------------------------------------------------------------
   Slide 12 — RP1 mechanism / strategy
   QMD: ## RP1: local injection with systemic intent

   Full replacement for the mechanism-slide portion.
   This uses slide-specific RP1 mechanism classes, so it should not disturb
   the RP1 approval slide or regulatory slide.
   --------------------------------------------------------------------- */

.rp1-mechanism-slide .lvd-content {
  top: 168px !important;
  left: 58px !important;
  right: 58px !important;
  bottom: 74px !important;
}

.rp1-mechanism-slide .signal-kicker {
  margin-top: 0;
}

/* Main mechanism strip ---------------------------------------------- */

.rp1-mechanism-slide .rp1-mechanism-stage {
  display: grid;
  grid-template-columns: 1fr 38px 1fr 38px 1fr 38px 1.12fr;
  gap: 18px;
  align-items: stretch;

  margin-top: 42px;
}

.rp1-mechanism-slide .rp1-mech-card {
  position: relative;
  box-sizing: border-box;

  min-height: 245px;
  padding: 30px 26px 26px;

  border: 1px solid var(--lvd-border);
  border-top: 8px solid var(--lvd-teal);
  border-radius: 14px;
  background: #fff;

  box-shadow: var(--shadow-soft);
}

.rp1-mechanism-slide .rp1-mech-card.highlight {
  border-top-color: var(--lvd-coral);
  background: linear-gradient(180deg, #ffffff 0%, #fbf1ee 100%);
  border-color: #e7c9c3;
}

.rp1-mechanism-slide .rp1-mech-node {
  display: flex;
  align-items: center;
  justify-content: center;

  width: 52px;
  height: 52px;
  margin-bottom: 30px;

  border-radius: 50%;
  color: #fff;

  font-size: 20px;
  line-height: 1;
  font-weight: 850;

  box-shadow: 0 7px 14px rgba(34,48,84,0.14);
}

.rp1-mechanism-slide .rp1-mech-node.teal { background: var(--lvd-teal); }
.rp1-mechanism-slide .rp1-mech-node.gold { background: var(--lvd-sand-dark); }
.rp1-mechanism-slide .rp1-mech-node.cobalt { background: var(--lvd-cobalt); }
.rp1-mechanism-slide .rp1-mech-node.coral { background: var(--lvd-coral); }

.rp1-mechanism-slide .rp1-mech-card strong {
  display: block;

  color: var(--lvd-navy);
  font-size: 27px;
  line-height: 1.08;
  font-weight: 820;
  letter-spacing: -0.02em;
}

.rp1-mechanism-slide .rp1-mech-card p {
  margin-top: 18px;

  color: var(--lvd-muted);
  font-size: 19px;
  line-height: 1.18;
}

.rp1-mechanism-slide .rp1-mech-arrow {
  display: flex;
  align-items: center;
  justify-content: center;

  color: var(--lvd-sand-dark);
  font-size: 40px;
  line-height: 1;
  font-weight: 850;
}

/* Bottom explanatory panels ----------------------------------------- */

.rp1-mechanism-slide .rp1-mechanism-bottom {
  display: grid;
  grid-template-columns: 0.86fr 1.14fr;
  gap: 34px;

  margin-top: 42px;
}

.rp1-mechanism-slide .rp1-dose-card,
.rp1-mechanism-slide .rp1-strategy-card {
  position: relative;
  box-sizing: border-box;

  min-height: 190px;
  padding: 34px 36px 26px;

  border: 1px solid var(--lvd-border);
  border-radius: 10px;
  background: #fff;

  box-shadow: var(--shadow-soft);
  overflow: hidden;
}

.rp1-mechanism-slide .rp1-dose-card {
  background: var(--lvd-soft-sand);
  border-color: #e0d1a9;
}

.rp1-mechanism-slide .rp1-strategy-card {
  background: #fff;
}

.rp1-mechanism-slide .rp1-dose-card .side-title,
.rp1-mechanism-slide .rp1-strategy-card .side-title {
  font-size: 29px;
  line-height: 1.04;
}

.rp1-mechanism-slide .rp1-dose-card p,
.rp1-mechanism-slide .rp1-strategy-card p {
  margin-top: 16px;

  color: var(--lvd-ink);
  font-size: 22px;
  line-height: 1.18;
}

.rp1-mechanism-slide .rp1-dose-card small {
  display: block;
  margin-top: 14px;

  color: var(--lvd-muted);
  font-size: 15px;
  line-height: 1.15;
}

.rp1-mechanism-slide .lvd-reference {
  bottom: 25px;
  font-size: 9px;
}
/* ---------------------------------------------------------------------
   Slide 13 — RP1 regulatory story
   QMD: ## Accelerated approval doesn't end the evidence discussion

   Full replacement for the RP1 regulatory slide.
   Uses slide-specific classes so it does not disturb the RP1 approval or
   mechanism slides.
   --------------------------------------------------------------------- */

.rp1-regulatory-slide .lvd-content {
  top: 168px !important;
  left: 58px !important;
  right: 58px !important;
  bottom: 74px !important;
}

.rp1-regulatory-slide .signal-kicker {
  margin-top: 0;
}

/* Main layout -------------------------------------------------------- */

.rp1-regulatory-slide .rp1-reg-layout {
  display: grid;
  grid-template-columns: 1fr 420px;
  gap: 34px;
  margin-top: 30px;
}

.rp1-regulatory-slide .rp1-reg-main {
  position: relative;
  box-sizing: border-box;

  min-height: 345px;
  padding: 34px 34px 30px;

  border: 1px solid var(--lvd-border);
  border-top: 9px solid var(--lvd-cobalt);
  border-radius: 12px;
  background: #fff;

  box-shadow: var(--shadow-soft);
}

.rp1-regulatory-slide .rp1-reg-kicker {
  color: var(--lvd-navy);
  font-size: 31px;
  line-height: 1.04;
  font-weight: 830;
}

/* Flow --------------------------------------------------------------- */

.rp1-regulatory-slide .rp1-reg-flow {
  display: grid;
  grid-template-columns: 1fr 28px 1fr 28px 1fr 28px 1fr 28px 1fr;
  gap: 10px;
  align-items: stretch;
  margin-top: 36px;
}

.rp1-regulatory-slide .rp1-reg-step {
  box-sizing: border-box;
  min-height: 185px;

  padding: 22px 20px 18px;

  border: 1px solid var(--lvd-border);
  border-radius: 11px;
  background: #fff;

  box-shadow: 0 8px 15px rgba(34,48,84,0.07);
}

.rp1-regulatory-slide .rp1-reg-step.coral-soft {
  background: var(--lvd-soft-coral);
  border-color: #e7c9c3;
}

.rp1-regulatory-slide .rp1-reg-step.cobalt-soft {
  background: #f0f3ff;
  border-color: #cdd4ef;
}

.rp1-regulatory-slide .rp1-reg-step.mint {
  background: var(--lvd-soft-teal);
  border-color: #bddcd7;
}

.rp1-regulatory-slide .rp1-reg-step.sand {
  background: var(--lvd-soft-sand);
  border-color: #e0d1a9;
}

.rp1-regulatory-slide .rp1-reg-year {
  color: var(--lvd-sand-dark);
  font-size: 18px;
  line-height: 1.05;
  font-weight: 840;
  margin-bottom: 18px;
}

.rp1-regulatory-slide .rp1-reg-step strong {
  display: block;
  color: var(--lvd-navy);
  font-size: 22px;
  line-height: 1.08;
  font-weight: 830;
}

.rp1-regulatory-slide .rp1-reg-step p {
  margin-top: 14px;
  color: var(--lvd-ink);
  font-size: 16px;
  line-height: 1.16;
}

.rp1-regulatory-slide .rp1-reg-arrow {
  display: flex;
  align-items: center;
  justify-content: center;

  color: var(--lvd-sand-dark);
  font-size: 32px;
  line-height: 1;
  font-weight: 850;
}

/* Sidebar ------------------------------------------------------------ */

.rp1-regulatory-slide .rp1-reg-sidebar {
  position: relative;
  box-sizing: border-box;

  min-height: 345px;
  padding: 38px 36px 30px;

  border: 1px solid #e0d1a9;
  border-top: 9px solid var(--lvd-sand);
  border-radius: 12px;
  background: var(--lvd-soft-sand);

  box-shadow: var(--shadow-soft);
}

.rp1-regulatory-slide .rp1-reg-sidebar .side-title {
  font-size: 30px;
  line-height: 1.04;
}

.rp1-regulatory-slide .rp1-reg-sidebar p {
  margin-top: 22px;
  color: var(--lvd-ink);
  font-size: 23px;
  line-height: 1.18;
}

.rp1-regulatory-slide .reg-callout {
  margin-top: 28px;
  padding-top: 24px;
  border-top: 2px solid #d8c182;

  color: var(--lvd-sand-dark);
  font-size: 23px;
  line-height: 1.20;
  font-weight: 780;
}

.rp1-regulatory-slide .reg-callout strong {
  color: var(--lvd-navy);
}

/* Bottom interpretation card ---------------------------------------- */

.rp1-regulatory-slide .rp1-reg-bottom {
  box-sizing: border-box;

  margin-top: 30px;
  min-height: 130px;
  padding: 20px 26px 16px;

  border: 1px solid var(--lvd-border);
  border-left: 10px solid var(--lvd-teal);
  border-radius: 10px;
  background: #eef2f7;

  box-shadow: var(--shadow-soft);
}

.rp1-regulatory-slide .rp1-reg-bottom .side-title {
  font-size: 28px;
  line-height: 1.04;
}

.rp1-regulatory-slide .rp1-reg-bottom p {
  margin-top: 16px;
  color: var(--lvd-ink);
  font-size: 24px;
  line-height: 1.18;
}

.rp1-regulatory-slide .lvd-reference {
  bottom: 25px;
  font-size: 9px;
}


/* ---------------------------------------------------------------------
   Slide 14 — Take-home
   --------------------------------------------------------------------- */
.takehome-grid { display: grid; grid-template-columns: repeat(3,1fr); gap: 30px; margin-top: 64px; }
.take-card { position: relative; min-height: 395px; border: 1px solid var(--lvd-border); border-radius: 12px; background: #fff; padding: 42px 38px; box-shadow: var(--shadow); overflow: hidden; }
.take-card::before { content: ""; position: absolute; top: 0; left: 0; right: 0; height: 12px; background: var(--lvd-teal); }
.take-card.cobalt::before { background: var(--lvd-cobalt); }
.take-card.coral::before { background: var(--lvd-coral); }
.take-card span { color: var(--lvd-sand-dark); font-size: 44px; line-height: 1; font-weight: 840; }
.take-card strong { display: block; margin-top: 28px; color: var(--lvd-navy); font-size: 31px; line-height: 1.10; font-weight: 810; }
.take-card p { margin-top: 28px; color: var(--lvd-muted); font-size: 28px; line-height: 1.22; }
.takehome-bottom { position: absolute; left: 0; right: 0; bottom: 34px; min-height: 88px; border-radius: 12px; background: linear-gradient(90deg, var(--lvd-sand) 0 12px, #eef2f7 12px 100%); border: 1px solid #ccd6e6; display: flex; align-items: center; padding-left: 40px; color: var(--lvd-navy); font-size: 31px; line-height: 1.05; font-weight: 810; }